反应详情

温度

0 °C

To a suspension of aluminum chloride (6.67 g) in dichloromethane (70 ml) was added hexanoyl chloride (7.0 ml) at 0° C. After the mixture was stirred at 0° C. for 15 minutes, isobutylbenzene (7.9 ml) was added to the mixture. The mixture was stirred at 0° C. for 30 minutes and poured into ice water. The separated organic layer was washed with water, aqueous sodium bicarbonate and brine. The solution was dried over magnesium sulfate and evaporated to give 4'-isobutylhexanophenone (10.52 g) as a colorless oil.

1. stirringThe mixture was stirred at 0° C. for 30 minutes
2. washThe separated organic layer was washed with water, aqueous sodium bicarbonate and brine
3. dry with materialThe solution was dried over magnesium sulfate
4. customevaporated