N-(4-nitrobenzyl)-N-(2-pyrimidinyl)amine → 4-[N-(2-pyrimidinyl)aminomethyl]aniline

HRID 24926Notes

Reaction equation

HRID 24926 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1>[Ni]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 22569285N-(4-nitrobenzyl)-N-(2-pyrimidinyl)amine

Product 1

HCID 111716394-[N-(2-pyrimidinyl)aminomethyl]aniline

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

Prepared analogously to Example 55 by catalytic hydrogenation of 4-(pyrimidin-2-ylaminomethyl)-nitrobenzene with Raney nickel.

Sources & evidence

ORD record
ord-ffb1c9ad683340ad880cfe05c723229b
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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