4-[N-(2-pyrimidinyl)aminomethyl]aniline → HCID 178517275, compound
Reaction equation
C(O[C:4](=[C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=2)[NH:13][C:12]1=[O:23])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)C.[N:24]1[CH:29]=[CH:28][CH:27]=[N:26][C:25]=1[NH:30][CH2:31][C:32]1[CH:38]=[CH:37][C:35]([NH2:36])=[CH:34][CH:33]=1>>[N:24]1[CH:29]=[CH:28][CH:27]=[N:26][C:25]=1[NH:30][CH2:31][C:32]1[CH:38]=[CH:37][C:35]([NH:36]/[C:4](=[C:11]2\[C:12](=[O:23])[NH:13][C:14]3[C:19]\2=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=3)/[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=2)=[CH:34][CH:33]=1Participants
3
Procedure
Prepared analogously to Example 89 by reacting 3-(1-ethoxy-1-phenyl-methylidene)-5-nitro-2-indolinone with 4-(pyrimidin-2-ylaminomethyl)-aniline.
Workup
- customPrepared analogously to Example 89
Sources & evidence
- ORD record
- ord-0b1f9cde1d2a4fa59da8620827fa4bb1
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06855710B2
Reaction notes
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