1H-Indole, 5-(phenylmethoxy)-1-(4-pyridinylmethyl)- → HCID 15292694, compound

Participants

Reaction Steps

To a suspension of 10% Pd/C (1.5 g) in 50 ml ethanol in a 500 ml Parr hydrogenation bottle, was added a suspension of 5-phenylmethoxy-1-(4-pyridinylmethyl)-1H-indole in 200 ml ethanol. The mixture was shaken at 50° C. under 50 psi hydrogen for one hour, then cooled, filtered, and the filtrate evaporated to a solid, 10 g, dec. 178° C. A sample of this material was eluted on a silica gel column with 2% methanol/dichloromethane via HPLC. The desired fractions were combined and evaporated to yield 2.3 g of 1-(4-pyridinylmethyl)-1H-indol-5-ol, as a solid, m.p. 185°-186° C.

Provenance & Evidence