反应详情

2-Chloro-4,5-difluorobenzoic acid (19.2 g, 0.1 mol) was mixed with thionyl chloride (50 ml) and heated to reflux for 3 hours. The reaction mixture was evaporated to dryness, and the residue dissolved in methylene chloride. Solvent was removed in vacuo, and the procedure repeated once with methylene chloride and once with benzene. The material (19 g, 0.09 mol, 90% yield) was used without further purification.

1. temperatureheated
2. temperatureto reflux for 3 hours
3. customThe reaction mixture was evaporated to dryness
4. dissolutionthe residue dissolved in methylene chloride
5. customSolvent was removed in vacuo