Methyl iodide → 2,2-Dimethyl-N-[2-(2,3-dihydro-1-methyl-1H-indol-2-yl)phenyl]propanamide

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Reaction Steps

To a mixture of 9.40 g K2CO3 and 10.05 g 2,2-dimethyl-N-[2-(2,3-dihydro-1H-indol-2yl)phenyl]propanamide in 125 ml DMF at 0° C., was added 3.64 ml iodomethane. The resulting mixture was stirred twenty-eight hours at room temperature. Upon dilution with water, a solid precipitated, which was collected and washed with water. Recrystallization from EtOH/water yielded 4.86 g solid, m.p. 133°-135° C.

Provenance & Evidence