Benzyl Chloride → HCID 2845263, compound

HRID 249350Notes

Reaction equation

HRID 249350 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][CH3:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH2:12](Cl)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 7503Benzyl ChlorideHCID 10340Sodium CarbonateHCID 197612651-[4-(Methylamino)piperidin-1-yl]ethan-1-one

Product 1

HCID 2845263HCID 2845263, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture containing 0.5 mol of the compound obtained in Stage A of Example 19, 0.5M benzyl chloride and 1M sodium carbonate in 650 ml of ethanol is refluxed for one night. The precipitate formed is filtered off, the solvent is evaporated, the evaporation residue is taken up in 1N hydrochloric acid and extracted with diethyl ether, and the ethereal extract is rendered basic with sodium hydroxide solution and extracted with ethyl acetate to obtain the desired compound.

Workup

  1. temperatureis refluxed for one night
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. customthe solvent is evaporated
  5. extractionextracted with diethyl ether
  6. extractionthe ethereal extract
  7. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-80149424651e4c6585a15e7b982377e3
Source dataset
uspto-grants-1993_05
Patent number
US05214055

Reaction notes

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