Diazomethane → HCID 19769486, compound

HRID 249386Notes

Reaction equation

HRID 249386 reaction equation
[N+](=[CH2:3])=[N-].[CH2:4]([O:11][C:12]1[CH:13]=[C:14]([C:19]([OH:25])([CH2:23][CH3:24])[C:20]([OH:22])=[O:21])[CH:15]=[C:16]([F:18])[CH:17]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(OCC)C>[CH2:4]([O:11][C:12]1[CH:13]=[C:14]([C:19]([OH:25])([CH2:23][CH3:24])[C:20]([O:22][CH3:3])=[O:21])[CH:15]=[C:16]([F:18])[CH:17]=1)[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 10470291HCID 10470291, compound

Product 1

HCID 19769486HCID 19769486, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of diazomethane in diethyl ether was added to a solution of (-)-2-(3-benzyloxy-5-fluorophenyl)-2-hydroxybutyric acid (2.24 g) in diethyl ether (35 ml) until the reaction mixture retained a yellow colouration. The mixture was evaporated to give methyl (-)-2-(3-benzyloxy-5-fluorophenyl)-2-hydroxybutyrate (2.27 g).

Workup

  1. customThe mixture was evaporated

Sources & evidence

ORD record
ord-0b39b1141fed48b0aaa51a516274fc0f
Source dataset
uspto-grants-1993_05
Patent number
US05214069

Reaction notes

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