Morpholine → HCID 14551021, compound

HRID 249401Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:7]([CH:11]([O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:12][C:13](O)=[O:14])([O:9][CH3:10])=[O:8]>>[CH3:10][O:9][C:7](=[O:8])[CH:11]([O:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[CH2:12][C:13]([N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)=[O:14]

Participants

Reactant 2

HCID 8083Morpholine

HCID 14551019HCID 14551019, compound

Product 1

HCID 14551021HCID 14551021, compoundYield 86%

Procedure

Using the mixed anhydride procedure described in Example 2, morpholine was coupled to 3-carbomethoxy-3-phenoxypropionic acid to give the desired product in 86% yield, mp 83°-84° C. Anal. Calcd for C15H19NO5 : C, 61.42; H, 6.53; N, 4.78. Found: C, 61.47; H, 6.50; N, 4.61.

Sources & evidence

ORD record: ord-57d47404169348df9f5fef6494092b67
Source dataset: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05214129

Reaction notes

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