反应详情

To a stirred solution of 155 g (0.83 mole) of 4-chloro-2-fluoroacetanilide in 400 ml of ethanol was added dropwise a solution of 72.0 g (1.8 moles) of sodium hydroxide in 100 ml of water. Upon completion of addition the reaction mixture was heated under reflux for three hours. The reaction mixture was cooled to ambient temperature and extracted with diethyl ether. The combined extracts were concentrated under reduced pressure to a residual oil. The oil was distilled under reduced pressure to yield 81.0 g of 4-chloro-2-fluoroaniline; b.p. 83-85/12 mm. The reaction was repeated several times.

1. additionUpon completion of addition the reaction mixture
2. temperaturewas heated
3. temperatureunder reflux for three hours
4. extractionextracted with diethyl ether
5. concentrationThe combined extracts were concentrated under reduced pressure to a residual oil
6. distillationThe oil was distilled under reduced pressure