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A sample of the above alcohol (140 g, 0.70 mole) was dissolved in toluene (400 ml) and thionyl bromide (80 ml, 0.77 mole) was introduced with vigorous stirring. After 1.5 h the exotherm reaction had subsided and diethyl ether (400 ml) was added. The resultant precipitate was collected by filtration and washed with diethyl ether. The solid was triturated with ethyl acetate, again collected on a filter and dried to provide (R)-1-(2-bromoethyl)nipecotic acid ethyl ester hydrobromide (175 g, 73%) as a white solid, m.p. 210°-215° C.

1. customAfter 1.5 h the exotherm reaction
2. filtrationThe resultant precipitate was collected by filtration
3. washwashed with diethyl ether
4. customThe solid was triturated with ethyl acetate
5. customagain collected on
6. filtrationa filter
7. customdried