反应详情

486 mg (1.0 mmol) of (Z)-3-{1-[4-(2-morpholinoethylamino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone (Example 332) are dissolved in 30 ml of dichloromethane and combined with 1.2 ml (16 mmol) of acetylchloride. The mixture is stirred for 1 hour at ambient temperature. The precipitate is removed by suction filtering and the reaction solution is washed with water. Then the solvent is eliminated in vacuo, the residue is dissolved in 20 ml of methanol and combined with 4 ml of 1 N sodium hydroxide solution. The mixture is stirred for 30 minutes at ambient temperature and then the solvent is eliminated in vacuo. The residue is suspended in water and a little ether. Then the product is suction filtered and dried.

1. customThe precipitate is removed by suction
2. filtrationfiltering
3. washthe reaction solution is washed with water
4. dissolutionthe residue is dissolved in 20 ml of methanol
5. stirringThe mixture is stirred for 30 minutes at ambient temperature
6. filtrationfiltered
7. customdried