HuagongsheHuagongshe Chemistry Print Report · For research reference only
Di-p-toluoyltartaric acid → 8-Methoxy-2-aminotetralin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Di-p-toluoyltartaric acid | HCID 12049127 | — |
| Reactant | N-benzyl-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine | HCID 12741413 | — |
| Product | 8-Methoxy-2-aminotetralin | HCID 10197933 | — |
Reaction Steps
The resolution is performed on 8-methoxy-2-(benzylamino)tetralin with the aid of (-)-di-p-toluoyltartaric acid according to Karlsson, et al., Acta Chem. Scand., B 42, 231-236 (1988). The enantiomers of 8-methoxy-2-(benzylamino)tetralin are debenzylated, yielding the corresponding enantiomers of 8-methoxy-2-aminotetralin, i.e., R-(+)- and S-(-)-8-methoxy-2-aminotetralin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05214156 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-e358c11ee4ab4afeb9c488842b9140a4 |
| Source note | uspto-grants-1993_05 |