HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-[(6-Chloro-3-pyridinyl)methylene]methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | 6-Chloropyridine-3-carbaldehyde | HCID 2764053 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-[(6-Chloro-3-pyridinyl)methylene]methanamine | HCID 53755856 | 68.1% |
Reaction Steps
In 30 ml of toluene, 0.8 g (5.7×10-3 moles) of 6-chloropyridine-3-aldehyde and 10 g of Na2SO4 were mixed and while the mixtures was stirred, a 40% aqueous solution of methylamine (1.4 g, 1.1×10-2 mole) was added dropwise over 30 minutes, followed by addition of 10 g of MgSO4. The mixture was allowed to stand at room temperature overnight, after which it was filtered. The filtrate was concentrated to give 0.6 g (yield 68%) of N-(6-chloro-3-pyridylmethylidene)methylamine as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05214152 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-5ab3656127a34542bf8a4841857a2604 |
| Source note | uspto-grants-1993_05 |