(2,6-Dichloropyridin-3-YL)methanamine → S-methyl-N-(6-chloro-3-pyridyl)-N-ethyl-N'-methylisothiourea

HRID 249522Notes

Reaction equation

HRID 249522 reaction equation
Cl[C:2]1C(CN)=CC=C(Cl)N=1.[Cl:11][C:12]1[N:17]=[CH:16][C:15]([N:18]([CH2:23][CH3:24])[C:19]([NH:21][CH3:22])=[S:20])=[CH:14][CH:13]=1.ClC1N=CC(N(C)C(NC)=S)=CC=1>>[CH3:2][S:20][C:19](=[N:21][CH3:22])[N:18]([C:15]1[CH:16]=[N:17][C:12]([Cl:11])=[CH:13][CH:14]=1)[CH2:23][CH3:24]

Participants

4

Reactant 3

HCID 15477284(2,6-Dichloropyridin-3-YL)methanamineHCID 22450332N-(6-chloro-3-pyridyl)-N-ethyl-N'-methylthioureaHCID 22450445N-(6-chloro-3-pyridyl)-N-methyl-N'-methylthiourea

Product 1

HCID 22450542S-methyl-N-(6-chloro-3-pyridyl)-N-ethyl-N'-methylisothiourea

Procedure

The reaction procedure of Example 59 (2) was repeated except that N-(6-chloro-3-pyridyl)-N-ethyl-N'-methylthiourea was used in lieu of N-(6-chloro-3-pyridyl)-N-methyl-N'-methylthiourea to give S-methyl-N-(6-chloro-3-pyridyl)-N-ethyl-N'-methylisothiourea as a pale yellow oil.

Sources & evidence

ORD record
ord-d99106a044474a4aa54cd0fb4358eec6
Source dataset
uspto-grants-1993_05
Patent number
US05214152

Reaction notes

Loading…