HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-Phenylbutyryl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-Phenylbutyric Acid | HCID 7012 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Phenylbutyryl chloride | HCID 98173 | 68% |
Reaction Steps
Thionyl chloride (0.12 mol) in 60 mL of CH2Cl2 was added to a stirred solution of 2-phenylbutyric acid (16.4 g, 0.10 mol). A catalytic amount of DMF was added and the reaction was allowed to continue overnight at room temperature. The volatiles were removed under vacuum and the residual liquid was vacuum distilled to yield 12.4 g (68%) of 2-phenylbutyryl chloride. IR (neat) 1798 cm-1 (C=O).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05214191 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-27d8209bcb5d425b9dd1ab8a3f96bc9c |
| Source note | uspto-grants-1993_05 |