Diazomethane → HCID 10082838, compound

HRID 249583Notes

Reaction equation

HRID 249583 reaction equation
[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][S:8][C:9]2[NH:13][N:12]=[N:11][N:10]=2)=[CH:5][CH:4]=1.[N+](=[CH2:18])=[N-]>CO.CCOCC>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][S:8][C:9]2[N:10]=[N:11][N:12]([CH3:18])[N:13]=2)=[CH:14][CH:15]=1

Participants

5

Reactant 2

HCID 9550DiazomethaneHCID 178491711HCID 178491711, compound

Product 1

HCID 10082838HCID 10082838, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 5-p-methoxybenzylthiotetrazole (7.00 g : 31.5 mMol.) in methanol (150 ml) is added under ice cooling a solution of diazomethane in ether (produced from 14 g of N-nitrosomethylurea), and the mixture is stirred for 1 hour and then concentrated. The residue is purified by Lobar column chromatography (toluene : ethyl acetate=5: 1) to give 5-p-methoxybenzylthio-2-methyltetrazole 4.86 g :

Workup

  1. concentrationconcentrated
  2. customThe residue is purified by Lobar column chromatography (toluene : ethyl acetate=5: 1)

Sources & evidence

ORD record
ord-f1bfc05e9a254621b2b03949eefe080f
Source dataset
uspto-grants-1993_05
Patent number
US05214037

Reaction notes

Loading…