Acetic Anhydride → 3-Acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methylthiophenyl)benzamide

HRID 2496Notes

Reaction equation

HRID 2496 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:33]=[CH:34][CH:35]=1)[C:5]([N:7]([CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24](=[O:32])[C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[CH2:20][CH2:19]1)[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([S:14][CH3:15])[CH:9]=1)=[O:6].[C:36](OC(=O)C)(=[O:38])[CH3:37]>>[C:36]([NH:1][C:2]1[CH:3]=[C:4]([CH:33]=[CH:34][CH:35]=1)[C:5]([N:7]([CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24](=[O:32])[C:25]2[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=2)[CH2:20][CH2:19]1)[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([S:14][CH3:15])[CH:9]=1)=[O:6])(=[O:38])[CH3:37]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 22356986HCID 22356986, compound

Product 1

HCID 223569653-Acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methylthiophenyl)benzamideYield 80.7%

Procedure

Using 3-amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methylthiophenyl)benzamide (196.7 mg, 0.40 mmol) and acetic anhydride (0.046 ml, 0.48 mmol), the procedure of Inventive Example 94 was repeated to obtain 172.2 mg (80.7%) of the title compound in a light brown amorphous form.

Sources & evidence

ORD record
ord-fbefbfc24389469fbc5d75415f5a85ff
Source dataset
uspto-grants-1998_03
Patent number
US05728835

Reaction notes

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