Trifluoroacetic acid → HCID 178520259, compound

Participants

Reaction Steps

To a suspension of 7β-phenylacetylamino-3-(1,2,3-triazol -4-yl)thiomethylthio-3-cephem-4-carboxylic acid diphenylmethyl ester (186 mg : 0.296 mMol ) in dichloromethane (3 ml) under ice cooling is added anisole (0.45 ml) and trifluoroacetic acid (0.45 ml), and the mixture is stirred for 1 hour 40 minutes. The reaction mixture is concentrated, triturated with hexane, and washed with ethyl acetate to give 7β- phenylacetylamino-3-(1,2,3-triazol-4-yl) thiomethylthio-3-cephem-4- carboxylic acid as white solid (67 mg). Yield : 49%.

Provenance & Evidence