Trifluoroacetic acid → HCID 178511446, compound

Participants

Reaction Steps

To a solution of 7β-(N-t-butoxycarbonyl-2-phenylglycylamino) -3- (trityl-1,2,3-triazol-4-ylthiomethylthio) -3-cephem-4-carboxylic acid diphenylmethyl ester (480 mg : 0.487 mMol.) in a mixture of anisole (1.2 ml) and dichloromethane (3 ml) under ice cooling is added trifluoro- acetic acid (3 ml), and the mixture is stirred under ice cooling for 30 minutes and at room temperature for 50 minutes. The reaction mixture is shaken with ice water and ethyl acetate under ice cooling. The aqueous layer is taken, concentrated to remove the remaining organic solvents under reduced pressure, and subjected to column chromatography over styrene-divinylbenzene copolymer resin (methanol : water=4:1). The residue is pulverized from ethyl acetate to give 7β-(2-phenylglycylamino)-3-(1,2,3-triazol -4-ylthiomethylthio)-3-cephem-4-carboxylic acid (157 mg) as white powder. Yield: 67%.

Provenance & Evidence