3,4-Difluoroaniline → HCID 178469610, compound

HRID 249675Notes

Reaction equation

HRID 249675 reaction equation
[OH:1][C:2]1C2C(=CC=CC=2)N=[CH:4][C:3]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].[F:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][C:24]=1[F:25])[NH2:21]>>[F:25][C:24]1[CH:23]=[C:22]2[C:20](=[CH:19][C:18]=1[F:17])[N:21]=[CH:4][C:3]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:2]2[OH:1]

Participants

3

Reactant 2

HCID 774693,4-DifluoroanilineHCID 178469510HCID 178469510, compound

Product 1

HCID 178469610HCID 178469610, compound

Procedure

The title compound was prepared following the procedure described Step 1 for the synthesis of 2a using 3,4-difluoroaniline instead of aniline. 1H NMR (DMSO-d6) δ (ppm): 1.15 (3H, t, J=7.08 Hz), 4.1 (2H, q, J=7.08 Hz), 7.61 (1H, dd, J=8.30, 2.93 Hz), 7.68 (1H, dd, J=4.63, 9.03 Hz), 7.80 (1H, dd, J=9.27, 2.93 Hz), 8.56 (1H, s). m/z 254.3 (MH+).

Sources & evidence

ORD record
ord-3aaf7672b99b47c0b3c7fb741126ea59
Source dataset
uspto-grants-2011_01
Patent number
US07863266B2

Reaction notes

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