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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 249682Generated: October 28, 2026

4-(Trifluoromethyl)aniline → Ethyl 4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate

https://huagongshe.com/reaction/249682

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)anilineHCID 9964—
ReactantHCID 178469510HCID 178469510—
ProductEthyl 4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylateHCID 178469538—

Reaction Steps

The title compound was prepared following the procedure described in Step 1 for the synthesis of 2a using 4-trifluoromethylaniline instead of aniline. 1H NMR (DMSO-d6) δ (ppm): 1.26 (3H, t, J=7.14 Hz), 4.22 (2H, q, J=7.14 Hz), 7.80 (1H, d, J=9.34 Hz), 8.00 (m), 8.39 (1H, s), 8.64 (1H, s). m/z 286.5 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07863266B2
Source datasetuspto-grants-2011_01
ORD IDord-dc6618985431472dac103e58b2e8124e
Source noteuspto-grants-2011_01