Sulfuric Acid → HCID 58085709, compound

Participants

Reaction Steps

[3-(2-Bromo-1,1-dimethoxyethyl)-5-pentafluorosulfanylphenyl]dimethylamine (230 mg) was suspended in water (2.3 ml) and then concentrated sulfuric acid (2.3 ml) was added dropwise with cooling. After stirring at RT for 2 h, the mixture was diluted with water (20 ml) and extracted three times with ethyl acetate. The combined organic phases were washed twice with saturated sodium hydrogencarbonate solution, dried over magnesium sulfate, filtered and concentrated. The residue was dissolved in acetonitrile/water, frozen and freeze-dried overnight. 170 mg of the desired compound were obtained.

Provenance & Evidence