反应详情

The deferoxamine B base was then suspended in a mixture of ethanol (3.1 L) and water (0.46 L). Methanesulfonic acid was slowly added until the deferoxamine B base dissolved and the solution reached a pH of 3.5. Another 30 L of ethanol was added to the solution to precipitate deferoxamine B mesylate. The resulting suspension was then cooled to between −5° C. and 0° C. and maintained at reduced temperature for 24 h. The crystals were isolated by filtration, washed with ethanol and dried under vacuum to yield deferoxamine B mesylate (299 g) with a purity of 98% (w/w) as determined by HPLC analysis.

1. dissolutiondissolved
2. customto precipitate deferoxamine B mesylate
3. temperatureThe resulting suspension was then cooled to between −5° C. and 0° C.
4. temperaturemaintained
5. customfor 24 h
6. customThe crystals were isolated by filtration
7. washwashed with ethanol
8. customdried under vacuum