Hydrochloric Acid → HCID 25000164, compound

Participants

Reaction Conditions

Reaction Steps

To 3-{3-[2,6-difluoro-3-(4-trifluoromethyl-benzenesulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-propionic acid methyl ester (P-0033, 215 mg, 0.38 mmol) dissolved in tetrahydrofuran (30 mL) was added 1 N lithium hydroxide solution (15 mL). The mixture was heated at 50° C. for 2 hrs, then acidified to pH˜1-2 with 6 N HCl and extracted with ethyl acetate. The organic layer was washed with water and brine dried over anhydrous magnesium sulfate, filtered and concentrated to provide an off-white solid (P-0034, 202 mg, 96%). MS(ESI) [M+H+]+=554.0.

Provenance & Evidence