HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride → (S)-2-morpholino-N-(quinuclidin-3-yl)benzo[d]oxazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride | HCID 12494973 | — |
| Reactant | 2-Morpholinobenzoxazole-4-carboxylic acid | HCID 66874397 | — |
| Product | (S)-2-morpholino-N-(quinuclidin-3-yl)benzo[d]oxazole-4-carboxamide | HCID 52943305 | — |
Reaction Steps
Following general procedure GP-C1, a mixture of 2-morpholinobenzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-morpholino-benzoxazole-4-carboxamide, which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863271B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-b7681d82640a475f8d793ccd1cab8e34 |
| Source note | uspto-grants-2011_01 |