4-Amino-1-methylpiperidine → HCID 58085869, compound

HRID 249835Notes

Reaction equation

HRID 249835 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[O:8][C:9]3[C:10](=[C:12]([C:16]([OH:18])=O)[CH:13]=[CH:14][CH:15]=3)[N:11]=2)[CH2:3][CH2:2]1.[NH2:19][CH:20]1[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]1>>[CH3:26][N:23]1[CH2:24][CH2:25][CH:20]([NH:19][C:16]([C:12]2[CH:13]=[CH:14][CH:15]=[C:9]3[O:8][C:7]([N:4]4[CH2:3][CH2:2][O:1][CH2:6][CH2:5]4)=[N:11][C:10]=23)=[O:18])[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 27375314-Amino-1-methylpiperidineHCID 668743972-Morpholinobenzoxazole-4-carboxylic acid

Product 1

HCID 58085869HCID 58085869, compound

Procedure

Following general procedure GP-C1, a mixture of 2-morpholinobenzoxazole-4-carboxylic acid and 4-amino-1-methylpiperidine were coupled to provide N-(1-methylpiperidin-4-yl)-2-morpholinobenzoxazole-4-carboxamide, which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.

Sources & evidence

ORD record
ord-6a53cda70f104d46ad0b67cb01f6417a
Source dataset
uspto-grants-2011_01
Patent number
US07863271B2

Reaction notes

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