참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Aminopyridine | HCID 1727 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | HCID 11155794 | — |
| 반응물 | Methyl 2-chlorobenzo[d]oxazole-4-carboxylate | HCID 56924368 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | tert-Butanol | HCID 6386 | — |
| 생성물 | Methyl 2-(pyridin-4-ylamino)benzoxazole-4-carboxylate | HCID 66873583 | — |
반응 단계
A mixture of methyl 2-chlorobenzoxazole-4-carboxylate (350 mg, 1.65 mmol), 4-aminopyridine (233 mg, 2.48 mmol), palladium(II) acetate (7.4 mg, 0.033 mmol), 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (39 mg, 0.083 mmol), K2CO3 (570 mg, 4.13 mmol) and t-BuOH (4 mL) was heated to 90° C. for 40 min. After cooling to room temperature, the reaction mixture was filtered through diatomaceous earth and concentrated. The crude product was purified by column chromatography (silica gel, 9:1 CH2Cl2/CH3OH) to afford methyl 2-(pyridin-4-ylamino)benzoxazole-4-carboxylate. 1H NMR and MS consistent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07863271B2 |
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| 출처 데이터셋 | uspto-grants-2011_01 |
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| ORD ID | ord-64aad37a3af54c31889d64be9c5b2f5a |
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| 출처 메모 | uspto-grants-2011_01 |
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