(S)-3-Ethylmorpholine → (S)-methyl 6-chloro-2-(3-ethylmorpholino)benzoxazole-4-carboxylate

HRID 249852Notes

Reaction equation

HRID 249852 reaction equation
[CH2:1]([C@H:3]1[CH2:8][O:7][CH2:6][CH2:5][NH:4]1)[CH3:2].Cl[C:10]1[O:11][C:12]2[C:13](=[C:15]([C:20]([O:22][CH3:23])=[O:21])[CH:16]=[C:17]([Cl:19])[CH:18]=2)[N:14]=1>>[Cl:19][C:17]1[CH:18]=[C:12]2[O:11][C:10]([N:4]3[CH2:5][CH2:6][O:7][CH2:8][C@@H:3]3[CH2:1][CH3:2])=[N:14][C:13]2=[C:15]([C:20]([O:22][CH3:23])=[O:21])[CH:16]=1

Participants

3

Reactant 2

HCID 28064334(S)-3-EthylmorpholineHCID 58085877Methyl 2,6-dichlorobenzoxazole-4-carboxylate

Product 1

HCID 66873630(S)-methyl 6-chloro-2-(3-ethylmorpholino)benzoxazole-4-carboxylate

Procedure

Following general procedure GP-A, (S)-3-ethylmorpholine and methyl 2,6-dichlorobenzoxazole-4-carboxylate were coupled to provide (S)-methyl 6-chloro-2-(3-ethylmorpholino)benzoxazole-4-carboxylate. MS consistent.

Sources & evidence

ORD record
ord-a7ec9ae034b243ca88019c768487a9d1
Source dataset
uspto-grants-2011_01
Patent number
US07863271B2

Reaction notes

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