Piperazin-2-one → HCID 66873515, compound

Participants

Reaction Steps

A mixture of methyl 2-chlorobenzoxazole-4-carboxylate (750 mg, 3.54 mmol) and piperazin-2-one (780 mg, 7.79 mmol) in THF (60 mL) was stirred at ambient temperature overnight. The reaction mixture was diluted with EtOAc (150 mL) and 1 N HCl (25 ml). The aqueous layer was separated, basified with 1 N NaOH and extracted with EtOAc (6×50 mL). The combined organic extracts were dried (Na2SO4) and concentrated under reduced pressure to give methyl 2-(3-oxopiperazine-1-yl)benzoxazole-4-carboxylate (690 mg, 72%). 1H NMR consistent.

Provenance & Evidence