HCID 53885227, compound → HCID 53722959, compound

Participants

Reaction Steps

A suspension of (R)-4-benzyl-3-((tert-butyldimethylsilyloxy)methyl)morpholine (576 mg, 1.79 mmol) and 10% palladium on carbon in EtOAc (20 mL) was placed in a Parr shaker and hydrogenated at 45 psi hydrogen pressure for 48 h. The heterogeneous mixture was filtered through a pad of diatomaceous earth, washed with CH3OH (200 mL) and concentrated to provide (R)-3-((tert-butyldimethylsilyloxy)methyl)morpholine (414 mg, quant.) as a colorless oil. MS consistent.

Provenance & Evidence