9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine;dihydrochloride → HCID 66873602, compound

HRID 249891Notes

Reaction equation

HRID 249891 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[O:15][C:16]3[C:17](=[C:19]([C:23]([O-:25])=O)[CH:20]=[CH:21][CH:22]=3)[N:18]=2)[CH2:10][CH:9]1[CH3:26])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Li+].Cl.Cl.[CH3:30][N:31]1[CH:36]2[CH2:37][CH2:38][CH2:39][CH:32]1[CH2:33][CH:34]([NH2:40])[CH2:35]2>>[CH3:26][CH:9]1[CH2:10][N:11]([C:14]2[O:15][C:16]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23](=[O:25])[NH:40][CH:34]4[CH2:33][CH:32]5[N:31]([CH3:30])[CH:36]([CH2:37][CH2:38][CH2:39]5)[CH2:35]4)[C:17]=3[N:18]=2)[CH2:12][CH2:13][N:8]1[C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7]

Participants

3

Reactant 2

HCID 189569979-Methyl-9-azabicyclo[3.3.1]nonan-3-amine;dihydrochlorideHCID 66874184HCID 66874184, compound

Product 1

HCID 66873602HCID 66873602, compound

Procedure

Following general procedure GP-C1, lithium 2-(4-(tert-butoxycarbonyl)-3-methylpiperazin-1-yl)benzoxazole-4-carboxylate and 9-methyl-9-azabicyclo[3.3.1]nonan-3-amine dihydrochloride were coupled to provide tert-butyl 2-methyl-4-(4-(9-methyl-9-azabicyclo[3.3.1]nonan-3-ylcarbamoyl)benzoxazol-2-yl)piperazine-1-carboxylate. MS consistent.

Sources & evidence

ORD record
ord-6e4068646461438e9cf5b04a8a795c08
Source dataset
uspto-grants-2011_01
Patent number
US07863271B2

Reaction notes

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