Lithium iodide → HCID 66874469, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2-((2S,6S)-2,6-dimethyl-4-(dimethylcarbamoyl)piperazin-1-yl)benzoxazole-4-carboxylate (265 mg, 0.74 mmol) in pyridine (5 mL) was added LiI (984 mg, 7.35 mmol). The mixture was heated at 110° C. for 14 h and allowed to cool to ambient temperature. The reaction was partially concentrated under reduced pressure before partitioning with 9:1 CH2Cl2/2-propanol (50 mL) and 1 N HCl (20 mL). The organic layer was washed with brine, dried (Na2SO4) and concentrated under reduced pressure to afford crude 2-((2S,6S)-2,6-dimethyl-4-(dimethylcarbamoyl)piperazin-1-yl)benzoxazole-4-carboxylic acid as an orange oil which was directly elaborated without purification.

Provenance & Evidence