Hydrochloric Acid → HCID 66874448, compound

Participants

Reaction Steps

To a vigorously stirred suspension of lithium 2-((2S,6S)-2,6-dimethylpiperazin-1-yl)benzoxazole-4-carboxylate (97 mg, 0.346 mmol) and NaHCO3 (87 mg, 1.037 mmol) in chloroform (6 mL) and H2O (6 mL) was added dropwise isobutyl chloroformate (54 mL, 0.415 mmol). The reaction mixture was stirred at room temperature for 2 h, then neutralized with 1N aqueous HCl, and concentrated under reduced pressure to provide 2-((2S,6S)-4-(isobutoxycarbonyl)-2,6-dimethylpiperazin-1-yl)benzoxazole-4-carboxylic acid. MS consistent.

Provenance & Evidence