Hydrochloric Acid → HCID 66874038, compound

Participants

Reaction Steps

To a vigorously stirred suspension of lithium 2-((2S,6S)-2,6-dimethylpiperazin-1-yl)benzoxazole-4-carboxylate (208 mg, 0.743 mmol) and NaHCO3 (187 mg, 2.23 mmol) in chloroform (12 mL) and H2O (2 mL) was added dropwise isopropylchloroformate (1M solution in toluene, 892 mL, 0.891 mmol). The reaction mixture was stirred at room temperature for 2 h, then neutralized with 1N aqueous HCl. The mixture was concentrated under reduced pressure to provide lithium 2-((2S,6S)-4-(isopropoxycarbonyl)-2,6-dimethylpiperazin-1-yl)benzoxazole-4-carboxylate. MS consistent.

Provenance & Evidence