反应详情

A solution of 5-(chloromethyl)-4-methyl-1-trityl-1H-imidazole (1.00 g, 2.68 mmol) in ammonia (7 N in CH3OH, 4 mL, 28 mmol) was heated to 50° C. in a sealed tube for 16 h. The reaction mixture was concentrated under reduced pressure and the crude material purified by column chromatography (silica gel, 100% CH2Cl2 to 50% CH3OH) to provide (4-methyl-1-trityl-1H-imidazol-5-yl)methanamine (250 mg, 26%). 1H NMR consistent.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe crude material purified by column chromatography (silica gel, 100% CH2Cl2 to 50% CH3OH)