Dichloromethane methanol → HCID 57788031, compound

HRID 249944Notes

Reaction equation

HRID 249944 reaction equation
[CH:1]1([NH:4][C:5]2[C:14]3[C:9](=[CH:10][C:11]([O:17][CH2:18][C:19]4[CH:20]=[C:21]([S:25]([CH2:33][CH3:34])(=[N:27]C(OCC)=O)=[O:26])[CH:22]=[CH:23][CH:24]=4)=[C:12]([O:15][CH3:16])[CH:13]=3)[N:8]=[CH:7][N:6]=2)[CH2:3][CH2:2]1.ClCCl.CO>CO>[CH:1]1([NH:4][C:5]2[C:14]3[C:9](=[CH:10][C:11]([O:17][CH2:18][C:19]4[CH:20]=[C:21]([S:25]([CH2:33][CH3:34])(=[NH:27])=[O:26])[CH:22]=[CH:23][CH:24]=4)=[C:12]([O:15][CH3:16])[CH:13]=3)[N:8]=[CH:7][N:6]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21226129Dichloromethane methanolHCID 57788024HCID 57788024, compound

Product 1

HCID 57788031HCID 57788031, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to GWP 6, the conversion of (RS)-S-[3-({[4-(cyclopropylamino)-6-methoxy-quinazolin-7-yl]oxy}methyl)phenyl]-N-(ethoxycarbonyl)-S-ethylsulphoximide (47 mg, 0.097 mmol) and chromatographic purification (silica gel, dichloromethane/methanol: 0→30% methanol) gives the desired product in 92% yield (37 mg).

Sources & evidence

ORD record
ord-d8579720b59e4df19cfe2d49d22f783e
Source dataset
uspto-grants-2011_01
Patent number
US07863283B2

Reaction notes

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