HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutylamine → HCID 57788012, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | HCID 57787972 | HCID 57787972 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 57788012 | HCID 57788012 | 91% |
Reaction Steps
According to GWP 5, the reaction of N′-(2-cyano-5-{3-[(RS)-N-(ethoxycarbonyl)-S-ethylsulphonimidoyl]benzyloxy}-4-methoxyphenyl)-N,N-dimethylformimidamide (50 mg, 0.11 mmol) with cyclobutylamine (9.1 mg, 0.13 mmol) and chromatographic purification (silica gel, dichloromethane/methanol: 0→30% methanol) gives the desired product in 91% yield (48 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863283B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-8be23dc0f14e4edfbc92457e5e8fbf6f |
| Source note | uspto-grants-2011_01 |