Dichloromethane methanol → HCID 57788019, compound

HRID 249948Notes

Reaction equation

HRID 249948 reaction equation
C(OC([N:6]=[S:7]([CH2:35][CH3:36])([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][O:16][C:17]2[CH:26]=[C:25]3[C:20]([C:21]([NH:27][C:28]4[S:29][CH:30]=[CH:31][N:32]=4)=[N:22][CH:23]=[N:24]3)=[CH:19][C:18]=2[O:33][CH3:34])[CH:10]=1)=[O:8])=O)C.ClCCl.CO>CO>[CH2:35]([S:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][O:16][C:17]2[CH:26]=[C:25]3[C:20]([C:21]([NH:27][C:28]4[S:29][CH:30]=[CH:31][N:32]=4)=[N:22][CH:23]=[N:24]3)=[CH:19][C:18]=2[O:33][CH3:34])[CH:10]=1)(=[NH:6])=[O:8])[CH3:36]

Participants

4

Reactant 2

HCID 21226129Dichloromethane methanolHCID 57788025HCID 57788025, compound

Product 1

HCID 57788019HCID 57788019, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to GWP 6, the conversion of (RS)-N-(ethoxycarbonyl)-S-ethyl-S-[3-({[6-methoxy-4-(thiazol-2-ylamino)quinazolin-7-yl]oxy}methyl)phenyl]-sulphoximide (40 mg, 0.076 mmol) and chromatographic purification (silica gel, dichloromethane/methanol: 0→30% methanol) gives the desired product in 66% yield (23 mg).

Sources & evidence

ORD record
ord-d196aa1cbaee4f3588fbb136053cad8f
Source dataset
uspto-grants-2011_01
Patent number
US07863283B2

Reaction notes

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