HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 44197697, compound → HCID 57787966, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 44197697 | HCID 44197697 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 57787966 | HCID 57787966 | 24% |
Reaction Steps
According to GWP 6, the conversion of (RS)-S-(3-{[(6-bromo-4-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}quinazolin-7-yl)oxy]methyl}phenyl)-N-(ethoxycarbonyl)-S-methylsulphoximide (45 mg, 0.081 mmol) and preparation thin layer chromatography (silica gel, dichloromethane/methanol: 4/1) gives the desired product in 24% yield (9 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863283B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-fd90505197504535ad65137572581e70 |
| Source note | uspto-grants-2011_01 |