Sodium ethoxide → HCID 57787987, compound

Participants

Reaction Steps

According to GWP 6, (RS)-S-[3-({[6-bromo-4-(2-hydroxyethylamino)quinazolin-7-yl]oxy}methyl)phenyl]-N-(ethoxycarbonyl)-S-methylsulphoximide (67 mg, 0.13 mmol) is reacted with sodium ethoxide (29 mg, 0.46 mmol) in ethanol (3 mL). After cooling to room temperature, the reaction mixture is admixed with brine and stirred for 30 minutes and the resulting precipitate is filtered off with suction to leave the desired product in 81% yield (47 mg).

Provenance & Evidence