Dichloromethane methanol → HCID 57787989, compound

HRID 249952Notes

Reaction equation

HRID 249952 reaction equation
C(OC([N:6]=[S:7]([CH3:36])([C:9]1[CH:14]=[CH:13][C:12]([CH2:15][O:16][C:17]2[CH:26]=[C:25]3[C:20]([C:21]([NH:27][C:28]4[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=4)=[N:22][CH:23]=[N:24]3)=[CH:19][C:18]=2[O:34][CH3:35])=[CH:11][CH:10]=1)=[O:8])=O)C.ClCCl.CO>CO>[CH3:35][O:34][C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][C:17]=1[O:16][CH2:15][C:12]1[CH:11]=[CH:10][C:9]([S:7]([CH3:36])(=[NH:6])=[O:8])=[CH:14][CH:13]=1)[N:24]=[CH:23][N:22]=[C:21]2[NH:27][C:28]1[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=1

Participants

4

Reactant 2

HCID 21226129Dichloromethane methanolHCID 57788023HCID 57788023, compound

Product 1

HCID 57787989HCID 57787989, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to GWP 6, the conversion of (RS)-N-(ethoxycarbonyl)-S-methyl-S-[4-({[6-methoxy-4-(3-pyridylamino)quinazolin-7-yl]oxy}methyl)phenyl]sulphoximide (33 mg, 0.064 mmol) and chromatographic purification (silica gel, dichloromethane/methanol: 0→30% methanol) gives the desired product in 61% yield (17 mg).

Sources & evidence

ORD record
ord-c68f9f39679345e08d88631d0a0619c8
Source dataset
uspto-grants-2011_01
Patent number
US07863283B2

Reaction notes

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