HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,4-Thiadiazol-2-amine → HCID 57788027, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,4-Thiadiazol-2-amine | HCID 19909 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | HCID 57788010 | HCID 57788010 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 57788027 | HCID 57788027 | 40% |
Reaction Steps
According to GWP 5, the reaction of N′-(2-cyano-5-{4-[(RS)-N-(ethoxycarbonyl)-S-methylsulphonimidoyl]benzyloxy}-4-methoxyphenyl)-N,N-dimethylformimidamide (85 mg, 0.19 mmol) with 2-amino-1,3,4-thiadiazole (23 mg, 0.22 mmol) and chromatographic purification (silica gel, dichloromethane/methanol: 0→30% methanol) gives the desired product in 40% yield (38 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863283B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-46d1cb3e1a72422299107c3e0fa56beb |
| Source note | uspto-grants-2011_01 |