HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane methanol → HCID 57787962, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | HCID 57788027 | HCID 57788027 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 57787962 | HCID 57787962 | 74% |
Reaction Steps
According to GWP 6, the conversion of (RS)-N-(ethoxycarbonyl)-S-methyl-S-[4-({[6-methoxy-4-(1,3,4-thiadiazol-2-ylamino)quinazolin-7-yl]oxy}methyl)-phenyl]sulphoximide (33 mg, 0.064 mmol) and chromatographic purification (silica gel, dichloromethane/methanol: 0→30% methanol) gives the desired product in 74% yield (21 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863283B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-73c1f6b095dd475eb7a52e1e23cc5903 |
| Source note | uspto-grants-2011_01 |