HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → HCID 44197698, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | HCID 57788030 | HCID 57788030 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 44197698 | HCID 44197698 | 74% |
Reaction Steps
According to GWP 6, conversion of (RS)-S-[3-({[4-(cyclopropylamino)quinazolin-7-yl]amino}methyl)phenyl]-N-(ethoxycarbonyl)-S-methylsulphoximide (58 mg, 0.13 mmol) and chromatographic purification (silica gel, n-hexane/ethyl acetate: 0→100% ethyl acetate, followed by dichloromethane/methanol: 0→25% methanol) gives the desired product in 74% yield (36 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863283B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-7b91d42cc94e4d7b93469ac883b9583c |
| Source note | uspto-grants-2011_01 |