HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane methanol → (RS)-S-Methyl-S-[3-({[4-(thiazol-2-ylamino)quinazolin-7-yl]amino}methyl)-phenyl]sulphoximide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | (RS)-N-(ethoxycarbonyl)-S-methyl-S-[3-({[4-(thiazol-2-ylamino)quinazolin-7-yl]amino}methyl)phenyl]sulphoximide | HCID 44197696 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (RS)-S-Methyl-S-[3-({[4-(thiazol-2-ylamino)quinazolin-7-yl]amino}methyl)-phenyl]sulphoximide | HCID 57788047 | 77% |
Reaction Steps
According to GWP 6, the conversion of (RS)-N-(ethoxycarbonyl)-S-methyl-S-[3-({[4-(thiazol-2-ylamino)quinazolin-7-yl]amino}methyl)phenyl]sulphoximide (40 mg, 0.083 mmol) and chromatographic purification (silica gel, dichloromethane/methanol: 0→20% methanol) gives the desired product in 77% yield (26 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863283B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-84bd8c8c80644c9cafa754f9157d2ce6 |
| Source note | uspto-grants-2011_01 |