Sodium Bicarbonate → HCID 57788035, compound

Participants

Reaction Conditions

Reaction Steps

According to GWP 6, (RS)-S-[3-({[6-bromo-4-(ethylamino)quinazolin-7-yl]oxy}methyl)-phenyl]-N-(ethoxycarbonyl)-S-methylsulphoximide (38 mg, 0.075 mmol) is dissolved in ethanol (5 mL), admixed with sodium ethoxide (19 mg, 0.27 mmol) and stirred at 60° C. for 3 hours. The reaction solution is admixed with saturated sodium bicarbonate solution and extracted with ethyl acetate. After drying of the organic phase over sodium sulphate and removal of the solvent, the residue is subsequently stirred up with methanol and the crystals are filtered off with suction to obtain the desired product in 45% yield (33 mg).

Provenance & Evidence