Sodium ethoxide → HCID 57787981, compound

Participants

Reaction Steps

According to GWP 6, (RS)-N-(ethoxycarbonyl)-S-[3-({[4(isopropylamino)quinazolin-7-yl]oxy}methyl)phenyl]-S-methylsulphoximide (68 mg, 0.16 mmol) is reacted with sodium ethoxide (46 mg, 0.68 mmol) at 80° C. for 2 hours. The reaction mixture is concentrated to dryness. The residue is taken up in ethyl acetate and water. The organic phase is separated off, dried over sodium sulphate and subsequently concentrated. The residue is triturated a number of times with diethyl ether and the solvent is subsequently decanted off. The residue is dissolved in dichloromethane and concentrated again. The desired product is obtained in 51% yield (30 mg).

Provenance & Evidence