反应详情

4-(Isopropylamino)-6-methoxyquinazolin-7-ol (65 mg, 0.21 mmol) and (RS)-S-[3-(bromomethyl)phenyl]-N-(ethoxycarbonyl)-S-methylsulphoximide (102 mg, 0.27 mmol) are suspended in 14 ml of acetone. After addition of caesium carbonate (2427 mg, 0.74 mmol), the reaction mixture is stirred at reflux for 3 hours. After cooling, the batch is concentrated, the residue is taken up in ethyl acetate, and the organic phase is washed with water and dried over sodium sulphate. After removal of the solvent, the residue (144 mg, 97% of theory) is employed in the next reaction without further purification.

1. temperatureat reflux for 3 hours
2. temperatureAfter cooling
3. concentrationthe batch is concentrated
4. washthe organic phase is washed with water
5. dry with materialdried over sodium sulphate
6. customAfter removal of the solvent
7. customthe residue (144 mg, 97% of theory) is employed in the next reaction without further purification