Dichloromethane methanol → HCID 86761248, compound

HRID 249982Notes

Reaction equation

HRID 249982 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][C:15]1[CH:16]=[C:17]([S:21]([CH3:29])(=[N:23]C(OCC)=O)=[O:22])[CH:18]=[CH:19][CH:20]=1)[N:9]=[CH:8][N:7]=[C:6]2[NH:30][CH:31]([CH3:33])[CH3:32])#[N:2].ClCCl.CO>CO>[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][C:15]1[CH:16]=[C:17]([S:21]([CH3:29])(=[NH:23])=[O:22])[CH:18]=[CH:19][CH:20]=1)[N:9]=[CH:8][N:7]=[C:6]2[NH:30][CH:31]([CH3:33])[CH3:32])#[N:2]

Participants

4

Reactant 2

HCID 21226129Dichloromethane methanolHCID 86761249HCID 86761249, compound

Product 1

HCID 86761248HCID 86761248, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to GWP 6, the conversion of (RS)-S-[3-({[6-cyano-4-(isopropylamino)-quinazolin-7-yl]oxy}methyl)phenyl]-N-(ethoxycarbonyl)-S-methylsulphoximide (65 mg, 0.14 mmol) and chromatographic purification (silica gel, dichloromethane/methanol: 0→30% methanol) gives the desired product in 74% yield (41 mg).

Sources & evidence

ORD record
ord-6b32615d3f304a23a96d99308af3ea41
Source dataset
uspto-grants-2011_01
Patent number
US07863283B2

Reaction notes

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